Below are some potential notable starts being made by drivers this weekend. Notable meaning they will be tied with a driver in number of starts made in that specific series, or the number of starts being made is a significant number that they are reaching in their specific race this weekend at Pocono Raceway. Rankings reflect the all-time starts list for that series.
(The image above each series is the driver I find having the most notable start this weekend)
*This will be updated after qualifying for each race if a driver does not make the race.

Tyler Ankrum makes milestone Truck start number 150 this weekend at Pocono. Image credit: @BMR_NASCAR X Page
Truck Series Starts
Tyler Ankrum: 150th start! Ranks 26th
Corey Heim: 78th start ties Aric Almirola, ranks 74th
Chandler Smith: 76th start ties Derek Kraus, Sheldon Creed & Ty Dillon, ranks 80th
Jack Wood: 75th start! Ranks 84th
Matt Mills: 60th start ties Carl Edwards & Scott Riggs, ranks 113th
Layne Riggs: 43rd start ties Matt DiBenedetto, ranks 170th
Connor Mosack: 25th start! Ties Jamie McMurray & Mark Martin, ranks 262nd
Frankie Muniz & Toni Breidinger: 18th start ties Chase Elliott, ranks 314th

Ryan Ellis will make his 147th career Xfinity start this weekend which ties him with 2x Xfinity Series Champion Dale Earnhardt Jr. for 111th most all-time. Image credit: @DGMRacingFL X Page
Xfinity Series Starts
Ryan Ellis: 147th start ties Buckshot Jones & Dale Earnhardt Jr., ranks 111th
Sam Mayer: 133rd start ties Austin Cindric, ranks 124th
Sheldon Creed: 119th start ties Kyle Larson, ranks 145th
Kyle Sieg: 97th start ties Josh Berry, ranks 177th
Chase Elliott: 87th start ties Chase Briscoe, ranks 202nd
Patrick Emerling: 57th start ties Alex Bowman & Ernie Irvan, ranks 257th
Leland Honeyman: 50th start!
Carson Kvapil: 25th start!
Logan Bearden: 10th start!

This weekend Brad Keselowski will tie NASCAR Legend and Hall of Famer, David Pearson by making his 574th career Cup start. Image credit: @RFKRacing X Page
Cup Series Starts
Brad Keselowski: 574th start ties David Pearson, ranks 37th
Austin Dillon: 425th start! Ranks 67th
Todd Gilliland: 125th start!
Carson Hocevar & Zane Smith: 62nd start ties Glen Wood, ranks 292nd
Riley Herbst: 25th start!