Below are some potential notable starts being made by drivers this weekend. Notable meaning they will be tied with a driver in number of starts made in that specific series, or the number of starts being made is a significant number that they are reaching in their specific race this weekend at Darlington Raceway. Rankings reflect the all-time starts list for that series.
(The image above each series is the driver I find having the most notable start this weekend)
*This will be updated after qualifying for each race if a driver does not make the race.

This weekend at Darlington Kaden Honeycutt makes his 63rd career Truck Series start which ties 3x Cup winner this year, Tyler Reddick, for 111th most all-time. Image credit: @NASCAR_Trucks X Page
Truck Series Starts
Grant Enfinger: 225th start! Ranks 15th
Josh Reaume: 86th start ties Bob Keselowski, ranks 66th
Kaden Honeycutt: 63rd start ties Tyler Reddick, ranks 111th
Layne Riggs & Taylor Gray: 58th start ties Ryan Blaney, ranks 123rd
Andres Perez de Lara: 31st start ties David Ragan, Jimmy Spencer & William Byron, ranks 216th
Frankie Muniz & Gio Ruggiero: 29th start ties Austin Cindric & Chase Briscoe, ranks 229th
Conner Jones: 28th start ties Daniel Suarez & Kurt Busch, ranks 243rd
William Sawalich: 22nd start ties David Gilliland, Geoff Bodine & Marcos Ambrose, ranks 289th

This weekend Matt DiBenedetto makes his 1st O’Reilly start of the year but his 128th career O’Reilly Series start which ties him with Harry Gant for 138th most all-time. Image credit: @J_G_Motorsports X Page
O’Reilly Auto Parts Series Starts
Ross Chastain: 216th start ties Kasey Kahne, ranks 59th
Garrett Smithley: 208th start ties Regan Smith, ranks 67th
Alex Labbe: 165th start ties Trevor Bayne & Ty Dillon, ranks 97th
Josh Bilicki: 133rd start ties Austin Cindric, ranks 128th
*Matt DiBenedetto: 128th start ties Harry Gant, ranks 138th
Patrick Staropoli: 10th start!
*Matt DiBenedetto did not qualify for the race and thus did not make his 128th career O’Reilly Series start

Ryan Preece ties a NASCAR Legend in Herb Thomas this weekend by making his 229th career Cup Series start. Image credit: @RFKracing X page
Cup Series Starts
Ricky Stenhouse Jr.: 478th start ties Jimmy Spencer, ranks 53rd
Austin Dillon: 450th start! Ranks 61st
Chris Buescher: 371st start ties Bobby Hamilton, ranks 79th
Chase Elliott: 364th start ties Alex Bowman & Rick Mast, ranks 81st
Ryan Preece: 229th start ties Herb Thomas, ranks 133rd
Tyler Reddick: 224th start ties Regan Smith, ranks 138th
Todd Gilliland: 150th start! Ranks 190th
Carson Hocevar & Zane Smith: 87th start ties Hershel McGriff & Kenny Irwin Jr., ranks 243rd
Shane Van Gisbergen: 56th start ties Buckshot Jones, ranks 305th
Riley Herbst: 50th start! Ranks 50th